Endocrine Abstracts

Background: It is well established that subclinical hypothyroidism (SCH) is associated with mild ventricular dysfunction and early cardiovascular disease (CVD), but it is unknown if there is an underlying defect in cardiac bio-energetic function.Objective: To quantify the cardiac phosphocreatine/ATP (PCr/ATP) ratio in SCH, compare with healthy controls (HC) and to measure the effect of 6 months of thyroxine treatment.Method: Cardia...

Background: Overt and subclinical hypothyroidisms are associated with altered cerebral blood flow (CBF) which may be reversed with levothyroxine treatment (T4T). Subclinical hypothyroidism (SCH) is associated with fatigue but it is unclear whether fatigue is related to abnormal CBF and whether T4T has a beneficial impact. We therefore studied fatigued SCH patients before and after T4T and euthyroid non-fatigued healthy controls (HC).Methods: CBF was meas...